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© CDR Ltd. 2008

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IPEG 2008

Professor Keith Wesnes made the plenary lecture at the 15th Biennial congress of the International Pharmaco-EEG Society in Rouffach. France, 25-26th September 2008. The lecture was entitled:

"Does integrating cognitive function testing and electroencephalography produce more than the sum of the parts?"

Full Article...

ISCTM - 2008 Autumn Conference

The conference titled "Advances in Conceptualization of Disease Progression in Alzheimer's Disease" will be held on 6th-7th October 2008, Yorkville, Toronto, CA.


CDR will be presenting on a poster on "A Computerized Cognitive Assessment System as an Alternative to the ADAS-cog in Dementia Trials"

Full Article...

GTCBio's 4th Neurodegenerative Diseases Drug Discovery Conference

Brian Saxby, Head of Science at CDR will be presenting on n "The Value of Automated Cognitive Testing in Developing Treatments for Neurodegenerative Diseases" on 9th-10th Oct, Philadelphia, PA

Full Article...

Ausbiotech 2008
CDR will be exhibiting at Ausbiotech 2008,  26th - 29th October, Melbourne Convention Centre, Australia.
Full Article...

2008 ACPU Annual Meeting
CDR will be exhibiting at the 2008 ACPU Annual Meeting hosted by Charles River Clinical Services on 20th-22nd October 2008. The event will be held at Hotel Murano, Washington, US.
Full Article...

CTAD 2008 - Clinical Trials on Alzheimer's Disease

CDR presented posters at the 1st Conference on Clinical Trials on Alzheimer's Disease (CTAD) held at Montpellier on 17th -19th September, 2008.

The aims of the meeting were to bring together the current leaders in clinical trials in Alzheimer’s Disease to discuss new results, drugs in development, and future methodological issues (disease modifying, outcomes, biomarkers, health economics).

 

 

Full Article...

Cognitive Drug Research paper selected by the American College Physicians Journal Club

CDR announce that a recently published study has been selected for inclusion in this month’s American College Physicians (ACP) Journal Club publication in Annals of Internal Medicine.

Full Article...

BPS -The Psychobiology Section - Annual Scientific Meeting
CDR presented at The BPS Annual Scientific Meeting held at Low Wood, The Lake District, UK 3-5 September 2008
Full Article...

16th Annual Alzheimer's Association Dementia Care Conference
CDR presented two posters at this event held at Garden Grove, California, 25-27 August 2008.

 

Full Article...

CPT 2008

The IXth World Conference on Clinical Pharmacology and Therapeutics 27th July - 1st August - Québec, Canada

CDR exhibited at booth # 102 and presented the following poster;
"Translational Medicine: Benefits of Computerized Cognitive Function Assessment in Routine Phase I Safety and Tolerability Trials of Cognition Enhancers" 

Full Article...

Prof Keith Wesnes examines the current hot topic in drug development, cognition enhancers, looking at the benefits they can have on a variety of mental capabilities working on a daily basis in European Pharmaceutical Contractor magazine (EPC)
Full Article...

ICAD 2008

Professor Keith Wesnes, Steve Satek and Brian Saxby from CDR presented posters at the ICAD meeting 2008 - Alzheimer's Association International Conference on Alzheimer's Disease on 26th - 30th July, Chicago, USA. 

 

Full Article...

XXVI CINP CONGRESS

Professor Keith Wesnes, Steve Satek and Nicole Meinel from CDR presented posters discussing "The Identification of Cognitive Enhancement in Man" on 13-17 July 2008 in Munich, Germany.

Full Article...

DIA's 44th Annual Meeting
CDR attended the 44th Annual Meeting held in Boston, MA on June 22 - 26 2008.
Full Article...

48th Annual NCDEU Meeting

Professor Keith Wesnes, Steve Satek and Patrick Turk of CDR each presented posters discussing "The Identification of Cognitive Enhancement in Man" at The 48th Annual NCDEU Meeting, 27-30 May - Scottsdale, AZ, USA

Full Article...

EPIC Biotech 2008
CDR attended this biotechnology conference which showcased over 60 UK and European biotechnology companies held on 22nd May 2008 at The Cumberland Hotel, London.
Full Article...

2nd Annual Exploratory Clinical Development Congress
CDR attended Europe's largest early development event held on 14th - 15th May, London.
Full Article...

APA Annual Meeting 2008

CDR attended the American Psychiatric Associations 161st Annual Meeting  on 3rd - 8th May, Washington, DC, USA. 

Full Article...

American Association for Technology in Psychiatry

CDR attended as delegates and Professor Keith Wesnes presented on "The Use of The CDR System, an Automated Test System for Assessing Cognitive Function in Drug Development" on 3rd May 2008, Washington, DC, USA.

Full Article...

CBI's Drug Development for Neurodegenerative Conditions

CDR exhibited and Professor Keith Wesnes presented on "Leverage the Value Cognitive Testing Brings to Phase I and II" in Arlington, VA, USA April 30th - May 1st 2008.

Full Article...

CDR PhD student success

We are delighted to announce that Crystal Haskell, one of Professor Keith Wesnes' PhD students, has recently been awarded her PhD from Northumbria University. Crystal was sponsored by CDR and used the CDR System to examine the biobehavioural effects of caffeine in isolation as well as in combination.

 

 

 

Full Article...

60th AAN Annual Meeting

CDR attended one of the world's largest gatherings of neurology professionals, which brought together more than 10,000 neurologists and neuroscientists to share groundbreaking research and participate in a comprehensive curriculum-based educational program: The 60th AAN Annual Meeting, April 12–19, 2008  Chicago, USA

Full Article...

BioTrinity 2008 Oxford
CDR attended the annual showcase event for the regional bioscience super-cluster, BioTrinity 2008 Oxford which brought together decision-makers from biotech and pharma together with expert professional advisers and VC finance representatives. April 15-16 2008, Oxford, UK.
Full Article...

Neurocognitive effects of herbal medicines: Two decades of clinical trials

Prof Keith Wesnes presented at the 3rd International Congress on Complementary Medicine Research  ‘ICCMR 2008', Sydney, Australia, 29 to 31 March 2008.

The title of his talk “Neurocognitive effects of herbal medicines: Two decades of clinical trials”, was presented at the following symposium: “Herbal medicines for brain and behaviour: from bench to bedside”

 

Full Article...

ICR's Communication in Clinical Research - "Challenges in a Complex World"

CDR attended The Insititute of Clinical Research - 29th Annual Conference & Exhibition 2008 8th & 9th April at the ICC, Birmingham, UK.

 

Full Article...

ASCPT 2008 Annual Meeting

CDR exhibited at booth number 110 and Steve Satek presented on "The Use of Cognitive Function Testing To Identify Potential Cognition Enhancers In Phase I: Case Histories of Translational Medicine" on April 02-05 2008, Orlando, Florida USA.

 

Full Article...

CNS Drug Development Summit

Brian Saxby, Head of Science at CDR, presented at The CNS Drug Development Summit on 2-3 April 2008, City Conference Centre, London, UK. 

The title of his talk was "Computerised cognitive testing in clinical trials of dementia prevention and cognitive decline: hypertension and stroke"

Full Article...

DIA's 20th Annual EuroMeeting 2008

CDR exhibited at DIA's 20th Annual EuroMeeting held in Barcelona Spain, 3rd - 5th March 2008

Full Article...

Hong Kong/Springfield Pan-Asian Symposium on Advances in Alzheimer Therapy - Feb 28th - 1st March 2008

Brian Saxby, Head of Science, presented a poster at the Hong Kong/Springfield Pan-Asian Symposium on Advances in Alzheimer Therapy.  

His poster number 24956 entitled "Measurement of Episodic Memory Using Word Tasks in Character-Based Languages: Validation From A Multicentre Clinical Trial.

Full Article...

December 2007: SURVEY FINDS INDUSTRY PROFESSIONALS PREFER CDR

 

Scientific knowledge, quality of test battery and breadth of experience cited as key reasons. 

A survey by a prominent U.S. marketing firm confirms that industry professionals prefer Cognitive Drug Research (CDR) for cognitive assessment studies.

Full Article...

International Clinical Trials publishes article on cognition testing and translational medicine written by CDR's scientific team

International Clinical Trials publishes an article written by CDR's scientific team on translational medicine and the utility of cognitive testing in routine phase 1 safety and tolerability trials in its autumn issue.

Full Article...

CDR short-listed for best CRO at the 2007 SCRIP Awards!

CDR were extremely proud to be selected alongside full service CROs in recognition of the services they provide in addition to cognitive testing - from protocol development, site training, 24h service, statistics and reporting to presentation of findings. These service assets set CDR apart from other test providers.

 

Full Article...

Amarin Corporation Plc (AMRN) announces Phase II trial using The CDR System in Age Associated Memory Impairment

Amarin Corporation Plc have announced the commencement of a Phase IIa trial in Age Associated Memory Impairment (AAMI) with AMR101 (ultra-pure ethyl-EPA).

The trial will be a randomised, double-blind, placebo-controlled study. The trial will enroll 96 patients with AAMI who will be randomised to receive 1, 2 or 4 grams of AMR101 or placebo twice daily over a six-week period.

A press release on 10th January 2008 highlighted that: 'Efficacy will be assessed by a computerised battery of cognition tests designed by Cognitive Drug Research (CDR) Ltd, a world leader in the provision of innovative cognitive function assessment technology'.

Full Article...

The British Psychological Society Psychobiology Section Annual Conference

Brian Saxby, Scientific Development Manager, spoke at the conference in the Lake District (3rd-5th September) about the relationship between blood biomarkers and cognitive recovery after cardiac surgery, assessed using the CDR System.

Full Article...

Alzheimer's Drug Development Summit

Professor Keith Wesnes presented at the Alzheimer's Drug Development Summit in the USA, November 29 - 30 2007, Arlington, VA.

Professor Wesnes spoke during the Day 2 section on early warning systems and novel cognitive assessment for Alzheimer's Disease, read on to find out more........

Full Article...

LEXICON initiates trial of drug candidate for cognitive disorders using CDR Battery

Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX) has announced that dosing has commenced in a Phase 2a clinical trial with LX6171, an oral drug candidate for the treatment of cognitive impairment associated with disorders such as Alzheimer's disease, schizophrenia, and vascular dementia.

Full Article...

Clinical Trials in CNS

Professor Keith Wesnes chaired Day 1 and spoke at SMi's Clinical Trials in CNS Conference in London on 26th & 27th November 2007.

The title of his talk was "Cognitive testing in drug development: latest developments and hot topics"

Full Article...

Great CDR test results on two prominent Alzheimer's Disease trials

CDR is delighted to announce that a paper based on data from the CDR System in two Alzheimer’s trials, one run in the UK and then other in the USA, has just been accepted for publication in the journal, Alzheimer’s Disease and Related Disorders.

Full Article...

American Association of Pharmaceutical Scientists (AAPS)

 

CDR exhibited at the American Association of Pharmaceutical Scientists annual meeting and exposition in San Diego, CA on 11th - 15th November 2007. This 21st annual meeting of the AAPS was the world’s largest gathering of pharmaceutical scientists The event was a huge success, with many people gathering at the CDR stand to try their hand in our Reaction Time Challenge to win a state of the art iPhone!

Full Article...

The SMi Group’s 8th Annual Pain Therapeutics Conference

 

CDR’s Scientific Operations Manager, Catherine Deeprose, gave an interesting and informative talk at this years Pain Therapeutics conference in London on Thursday 1st November, 2007. The title of Catherine's talk was 'PAIN, PAIN THERAPIES AND COGNITIVE FUNCTION'. 

Full Article...

Partnerships in Clinical Trials 2007

 

CDR exhibited at the 6th Annual Partnerships in Clinical Trials (PCT) held in Amsterdam on 5th - 8th November 2007. PCT is the largest gathering of Clinical Trials Outsourcing professionals in Europe. The event was a real success and sessions were interesting and informative. CDR look forward to next years PCT!

Full Article...

Neuren Pharmaceuticals cite The CDR System as ‘a well-recognised and accepted endpoint’

CDR is currently involved in a pivotal Phase II trial to investigate the benefits of Glypromate in reducing cognitive impairment in cardiac surgery patients.

Full Article...

International Psychogeriatric Association Silver Congress in Osaka, Japan, 14th-18th October

Brian Saxby, Scientific Development Manager at CDR, presented in the Hot Topics session on Thursday 18th October on the relationship between homocysteine, cognitive decline and brain atrophy.

Full Article...

CDR attention tasks predict 1-year outcome in poststroke urinary incontinence

A study in the October issue of the Journal of the American Geriatrics found that patients who developed urge urinary incontinence after stroke had poorer CDR Power of Attention and Speed of Memory scores than those that remained continent. Patients with impaired awareness of the need to void performed poorest of all. In regression analyses, Continuity of Attention and impaired awareness were the strongest predictors of poor outcome after 1 year.

Full Article...

Cognitive testing in children
The utility of the CDR system for testing cognition in children has again been demonstrated in a paper published in the International Journal of Ventilation.
Full Article...

CDR battery is preferred to pencil-and-paper tasks by the oldest old, and test administrators
A study published in the October issue of the Journal of the American Geriatrics Society found that 85 year old participants and test administrators both preferred computerised cognitive testing using the CDR battery compared to pencil-and-paper tasks from the Wechsler Adult Intelligence Scale (WAIS) III.
Full Article...

Kellogg's uses CDR to support its advertising!

A recently launched advertising campaign for Rice Krispies, the well known children’s breakfast cereal, demonstrates CDR’s excellent results in a breakfast study held in the UK in 2003. Read on to find out more…….

 

Full Article...

Drug Development for Cognitive Therapeutics: Tackling Cognition from Bench to Bedside

Professor Keith Wesnes spoke at this exciting event on the 6-7th September 2007 in London. With a focus on the early use of cognitive testing being a predictor of outcomes in later phase studies, this talk interested all who attended. For details of the talk please read on........

Full Article...

CDR: The missing piece of the jigsaw in your clinical trial
A recent review in The Lancet concluded that there is an urgent need for further robust clinical evidence on the risks and benefits of medicines taken by elderly patients. Evidence such as this highlights the importance of covering every angle in any clinical trial - CDR is the missing piece of the jigsaw in elderly clinical trials. Testing cognitive function is of paramount importance to give a complete picture.......

Full Article...

CDR presents four posters at the annual New Clinical Drug Evaluation Unit (NCDEU) meeting held in Boca Raton, Florida, USA on June 11-14, 2007

The NCDEU Meeting is a scientific conference bringing together academic researchers from multiple disciplines involved in clinical trials, investigators within the pharmaceutical industry, and representatives from the National Institute of Mental Health/National Institutes of Health (NIMH/NIH) and the Food and Drug Administration (FDA) to address psychopharmacology, clinical trials methodology, and the broader areas of interventions and services research.

Full Article...

Kidney Disease study demonstrates CDR’s utility in large Multi-Centre Trials

In a paper entitled, Cognitive function in Stage 5 chronic kidney disease patients on hemodialysis: No adverse effects of lanthanum carbonate compared with standard phosphate-binder therapy’, the CDR System was clearly labelled as an easily utilised detection measure of cognitive change.

Full Article...

International Society for Vascular Behavioural and Cognitive Disorders: VAS-COG 2007

Brian Saxby, Scientific Development Manager, presented at VAS-COG 2007 in San Antonio, Texas, on Friday 13th July.
Full Article...

CDR in South Africa
CDR exhibited at the South African Clinical Research Association (SACRA) Conference, on the 2nd-3rd August 2007 in Johannesburg.
Full Article...

DIA Atlanta 17th-21st June 2007

CDR exhibited at this year's 43rd Drug Information Association (DIA) conference in Atlanta USA. The Chicago based Business Development Team were supported by our MD, Jo Christodoulou, and all found the event an ideal opportunity to network and discuss forthcoming opportunities.  

Full Article...

British Association of Psychopharmacology (BAP) Summer Meeting
CDR were, once again, present at this year's annual summer meeting of the BAP. This year the event was held in Harrogate, UK from 22nd-25th July 2007.
Full Article...

Blackmore’s Research Symposium: 6-7th July 2007, Four Seasons Hotel, Sydney, Australia
CDR are pleased to announce Professor Keith Wesnes spoke at this exciting event Down Under!
Full Article...

July Melbourne Visit - Centre for Healthy Ageing/Research symposium on Healthy Ageing
CDR are pleased to announce that Professor Keith Wesnes spoke at the Centre for Healthy Ageing/Research symposium on Healthy Aging on Friday July 13th in Melbourne, Australia.
Full Article...

CDR data included in kidney dialysis study; published in Kidney International, the official journal of the International Society of Nephrology.
The 360-participant study examined cognitive decline associated with lanthanum carbonate therapy in hemodialysis patients. Results demonstrated no more adverse effects in patients receiving lanthanum carbonate than in those receiving standard therapy.
Full Article...

Effect on cognitive function as measured by the CDR Battery is primary outcome measure in Memory Pharmaceuticals' Phase 2a Trial
Memory Pharmaceuticals Commences Phase 2a Trial Of MEM 3454 In Alzheimer's Disease
Full Article...

Fapronatura 2006 Poster Prize success
A study using the CDR system to investigate the cognitive and mood effects of caffeine and L-theanine has scooped the award for best poster presentation at the Fapronatura 2006 conference in Cuba.
Full Article...

CDR and Pharma
CDR Helps Memory Pharmaceuticals Show Cognitive Enhancement in Volunteers
Full Article...

CLINILABS AND COGNITIVE DRUG RESEARCH FORM STRATEGIC ALLIANCE
Clinilabs, Inc. and Cognitive Drug Research (CDR) have formed a non-exclusive strategic alliance, bringing together two leaders in CNS clinical trials to provide an optimal environment for cognition assessment. CDR’s gold standard cognition assessment equipment will be permanently hosted at Clinilabs’ premier phase I-IV research site in New York City. The creation of this ‘super-site’ offers clients a one-stop-shop for cognition assessment, bringing with it the advantages of ready trained site staff, expert consultation on cognition assessment and a full range of clinical trial site services.
Full Article...

CDR attention tasks shown to reflect core activity of daily living deficits in Parkinson's disease dementia.
Attentional deficits affect activities of daily living in dementia associated with PD

A paper just published (June 26th, 2006) online in the Journal of Neurology, Neurosurgery & Psychiatry shows that in Parkinson's dementia, attentional dysfunction assessed using the CDR attention battery is one of the primary cognitive factors involved in functional impairment in the disorder.
Full Article...



IPEG 2008

Professor Keith Wesnes made the plenary lecture at the 15th Biennial congress of the International Pharmaco-EEG Society in Rouffach. France, 25-26th September 2008. The lecture was entitled:

"Does integrating cognitive function testing and electroencephalography produce more than the sum of the parts?"


The IPEG society is largely involved in promoting the use of electroencephalography (EEG) and related techniques in drug research from animal to clinic. Since the first EEG publications in the beginning of the 20th century, EEG discipline has known a continuous evolution. The most recent innovations of EEG are its use in multi-modal approaches to improve our knowledge of brain activity.

The aim of the present IPEG meeting was to discuss the latest advances in research and issues regarding the use of EEG and EEG-related techniques in neurology, psychiatry, anesthesia and analgesia in a drug development perspective. Since interdisciplinary and international exchange can lead to a fruitful emergence of new ideas, experts and professionals from different countries and different disciplines across academia and industry participated in this meeting.
As previous IPEG congresses, the IPEG symposia started with training courses designed to provide basic and advanced information on the different aspects of electroencephalography (EEG) / magnetoencephalography (MEG) research: principles, recording procedures, experimental designs, data analysis and interpretation, with applications in different fields of neuropsychopharmacology.

 

For further details on Professor Wesnes' talk Click Here

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ISCTM - 2008 Autumn Conference

The conference titled "Advances in Conceptualization of Disease Progression in Alzheimer's Disease" will be held on 6th-7th October 2008, Yorkville, Toronto, CA.


CDR will be presenting on a poster on "A Computerized Cognitive Assessment System as an Alternative to the ADAS-cog in Dementia Trials"


Alzheimer’s Disease is a neurodegenerative disease with large unmet needs for preventing or slowing both its onset and progression. Attempts to fill these gaps in treatment present numerous clinical and regulatory challenges including diagnostic accuracy, establishing clinically valid endpoints, developing clinically feasible and ethically justifiable study designs that would also meet regulatory needs.

 

To register for this event Click Here. To meet with CDR at this event Click Here.

close

GTCBio's 4th Neurodegenerative Diseases Drug Discovery Conference

Brian Saxby, Head of Science at CDR will be presenting on n "The Value of Automated Cognitive Testing in Developing Treatments for Neurodegenerative Diseases" on 9th-10th Oct, Philadelphia, PA


The drug discovery effort for neurodegenerative diseases has been one of the major challenges and focuses of the pharmaceutical industry, which has been evidenced by fast and dynamic research and development in this field. In the last few years, there has been great progress in the development of novel therapeutic approaches to treat Alzheimer’s, Parkinson’s, Huntington’s, multiple sclerosis, stroke and various other neurodegenerative diseases. There have also been significant developments in our understanding of the genetics, the molecular mechanisms and signaling pathways contributing to neuronal dysfunction, neurotoxicity and pathology.

At GTCbio’s 4th annual Neurodegenerative Diseases Drug Discovery conference, leading scientists and experts will discuss these latest breakthroughs, new drug targets, new models, the development of new biomarkers, imaging modalities, improved clinical trial designs and several other novel developments and therapeutics to combat neurodegenerative conditions.

To register for this event Click Here. To meet with Brian Saxby at this event Click Here.

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Ausbiotech 2008

CDR will be exhibiting at Ausbiotech 2008,  26th - 29th October, Melbourne Convention Centre, Australia.

AusBiotech 2008 is the premier biotechnology conference for the Asia Pacific region. A comprehensive conference program together with an extensive BioIndustry Exhibition and Business Matching Program will bring together representatives from the global biotechnology industry to create a world leading event.  

To register for this event Click Here. To meet with CDR at this Ausbiotech Click Here

close

2008 ACPU Annual Meeting

CDR will be exhibiting at the 2008 ACPU Annual Meeting hosted by Charles River Clinical Services on 20th-22nd October 2008. The event will be held at Hotel Murano, Washington, US.

Dr Royce Morrison, Director of Clinical Strategy and Colleen Hoke, Sr. Director Global Phase I Business Development at Charles River Clinical Services Northwest are this year’s Program Co-chairs. They have assembled a very exciting program. To view this program click here.

For further details on this event click here. To meet with CDR at ACPU 2008 click here.

 

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CTAD 2008 - Clinical Trials on Alzheimer's Disease

CDR presented posters at the 1st Conference on Clinical Trials on Alzheimer's Disease (CTAD) held at Montpellier on 17th -19th September, 2008.

The aims of the meeting were to bring together the current leaders in clinical trials in Alzheimer’s Disease to discuss new results, drugs in development, and future methodological issues (disease modifying, outcomes, biomarkers, health economics).

 

 


Steve Satek, Director of Operations, USA for CDR presented posters on the following;

"Identifying Cognitive Enhancement In Man: Adding Testing To Routine Phase I Trials"

"Identifying Cognitive Enhancement In Man: Identifying Efficacy In The Dementias"

To view these posters click here

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Cognitive Drug Research paper selected by the American College Physicians Journal Club

CDR announce that a recently published study has been selected for inclusion in this month’s American College Physicians (ACP) Journal Club publication in Annals of Internal Medicine.


 

The ACP Journal Club review key papers from the published literature according to criteria of scientific merit and assessment of relevance to medical practice by clinical specialists.

 

The paper, published in Neurology, presents the results of a cognitive substudy of the Study on Cognition and Prognosis in the Elderly (SCOPE) in which the CDR computerised assessment battery was used to measure cognition in older adults over a 4-year period. The results suggest that treatment of hypertension with the angiotensin-receptor-blocker candesartan may reduce the rate of decline in the areas of attention, episodic memory and cognitive speed. The comprehensive assessment of cognitive function using the sensitive CDR battery found benefits to cognition that were not detected in the main SCOPE trial despite the larger sample size.

 

“The substudy of the SCOPE trial showed that it is feasible to perform detailed assessments of cognition in the elderly in later phase primary prevention trials. We are delighted the Neurology paper has been included in the ACP Journal Club and received such high ratings for quality”, said Brian K. Saxby, lead author and Head of Science at CDR Ltd.

 

Citation for original paper: Saxby B K, Harrington F, McKeith I G, Wesnes K and Ford G A (2008). Candesartan and cognitive decline in older patients with hypertension: A substudy of the SCOPE trial. Neurology 70: 1858-1866.

 

To view the paper click here. For further information please contact, Brian K Saxby, Head of Science at CDR Ltd Email: brians@cdr.eu.com

 


BPS -The Psychobiology Section - Annual Scientific Meeting

CDR presented at The BPS Annual Scientific Meeting held at Low Wood, The Lake District, UK 3-5 September 2008

Oliver West, Scientific Project Researcher at CDR spoke on 'The Development of a computerised analogue of the Mirror Tracing Task'

Brian Saxby, Head of Science at CDR presented a poster on 'Association of Plasma Homocysteine Concentrations with Cognitive Decline and Brain Atrophy in Older People with Hypertension'

Helen Brooker, Collaborative Researcher at CDR presented a poster on 'Different Glycaemic Index and Insulin Response Profile Foods: Effect of Breakfast on Memory and Attention in School Children'

To request a copy of the posters click here

 

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16th Annual Alzheimer's Association Dementia Care Conference

CDR presented two posters at this event held at Garden Grove, California, 25-27 August 2008.

 


Now in its 16th year, the Alzheimer's Association Dementia Care Conference provided care professionals with the opportunity to connect with peers from around the country; learn from renowned aging experts; and participate in educational programs tailored to address the unique needs and demands of the profession.

CDR presented posters on the following;

Identifying Cognitive Enhancement in Humans: Efficacy in the Dementias

Identifying Cognitive Enhancement in Man: Model and Plarmacodynamic Trials in Volunteers

To request a copy of these posters Click Here

close

CPT 2008

The IXth World Conference on Clinical Pharmacology and Therapeutics 27th July - 1st August - Québec, Canada

CDR exhibited at booth # 102 and presented the following poster;
"Translational Medicine: Benefits of Computerized Cognitive Function Assessment in Routine Phase I Safety and Tolerability Trials of Cognition Enhancers" 


The World Conference on Clinical Pharmacology and Therapeutics is an international meeting held every four years as a forum for clinical and basic pharmacologists from universities, hospitals, government laboratories, as well as from regulatory bodies and the pharmaceutical industry (including Biotech, CRO and other service companies).

For CPT 2008 in Québec City, 2500 physicians, pharmacists, researchers, university professors and graduate students from all over the world attended.

To request a copy of the poster Click Here

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Prof Keith Wesnes examines the current hot topic in drug development, cognition enhancers, looking at the benefits they can have on a variety of mental capabilities working on a daily basis in European Pharmaceutical Contractor magazine (EPC)


The simplest working definition of cognition enhancement is the improvement of one or more aspects of mental function.This article will illustrate some of the key issues facing the development of cognition enhancers, which include focusing and sustaining attention, information processing, decision-making, holding information online, and retaining memory for names, events and experiences.

To view the article click here

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ICAD 2008

Professor Keith Wesnes, Steve Satek and Brian Saxby from CDR presented posters at the ICAD meeting 2008 - Alzheimer's Association International Conference on Alzheimer's Disease on 26th - 30th July, Chicago, USA. 

 


Posters presented were:

The Role Of Nicotinic Receptors In Human Cognitive Function.

Identifying Cognitive Enhancement In Man: Adding Testing To Routine Phase I Trials.

Identifying Cognitive Enhancement In Man: Identifying Efficacy In The Dementias.

Identifying Cognitive Enhancement In Man: Models And Pharmacodynamic Trials In Volunteers

Identifying Cognitive Enhancement In Man: Showing Benefits in Conditions in which Cognitive Deficits are Secondary.

A Computerized Cognitive Assessment System as an Alternative to the ADAS-cog in Dementia Trials.

If you would like to request a copy of the posters Click Here

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XXVI CINP CONGRESS

Professor Keith Wesnes, Steve Satek and Nicole Meinel from CDR presented posters discussing "The Identification of Cognitive Enhancement in Man" on 13-17 July 2008 in Munich, Germany.


The Scientific Programme covered all aspects of treatment of CNS disorders from basic to clinical research, and the newest concepts for improving the life of patients with mental and neurological disorders was presented. Through symposia, poster sessions, educational workshops and expert sessions, the Congress brought together basic and clinical scientists from around the world. In addition, highly interesting scientific symposia, satellite events and ex-hibitions was organized by pharmaceutical companies, offering new and valuable information to the audience.

To request a copy of the posters presented Click Here

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DIA's 44th Annual Meeting

CDR attended the 44th Annual Meeting held in Boston, MA on June 22 - 26 2008.

The DIA Annual Meeting represents the most significant means for advancing our objectives via our multidisciplinary focus, international reach, and neutral forums. The 44th Annual Meeting offered innovative ideas, provided answers to new questions, and helped the pharmaceutical industry redefine the development, regulation, surveillance, and marketing of pharmaceuticals.

 

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48th Annual NCDEU Meeting

Professor Keith Wesnes, Steve Satek and Patrick Turk of CDR each presented posters discussing "The Identification of Cognitive Enhancement in Man" at The 48th Annual NCDEU Meeting, 27-30 May - Scottsdale, AZ, USA


The NCDEU Meeting was a scientific conference that brought together academic researchers from multiple disciplines involved in clinical trials, practicing psychologists, research pharmacists, nurses, and social workers, as well as investigators with the pharmaceutical industry, and representatives from NIMH/NIH and the Food and Drug Administration (FDA).

In addition to the meeting's central focus was on the latest developments in psychopharmacologic clinical research and related methodology, the meeting program expanded to encourage presentations on a broad range of interventional, translational, drug and other treatment development, and economic and policy research to increase the impact of psychopharmacology trials. The program emphasized the presentation of information that has not been published or presented in the past.

The NCDEU meeting continued to provide a forum for multidisciplinary approaches and crosstalk among basic neuroscientists, clinical researchers, and services researchers. In addition, the meeting  addressed a number of timely issues relevant to clinical research in psychiatry, such as the translation of research findings into practice, the importance of regulatory issues, and pharmacogenetics.

To view that posters that were presented by CDR email enquiries@cdr.eu.com

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EPIC Biotech 2008

CDR attended this biotechnology conference which showcased over 60 UK and European biotechnology companies held on 22nd May 2008 at The Cumberland Hotel, London.

Two of the streams this year focused on companies with products in either pre-clinical or clinical trial stages. These were of particular interest to pharmaceutical and biotechnology companies, venture capital companies and CROs. Having over 60 biotechnology companies presenting in one day makes EPIC a cost-effective day of evaluating companies for investment. The very popular University Challenge session again features along with one for Platform Technologies and Diagnostics.

 

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2nd Annual Exploratory Clinical Development Congress

CDR attended Europe's largest early development event held on 14th - 15th May, London.

The Second Annual Exploratory Clinical Development Congress followed the huge success of the 2007 meeting where a record number of early development scientists explored the challenges of Phase I Trials.


In 2008, early development remains at a critical stage. The transition to first in man has crucial regulatory, scientific and operational issues that need to be confronted head on in order to avoid high costs and high profile product failures. Safety concerns continue to dominate and following recommendations from the ESG Working Group, the ABPI has revised its guidelines for Phase I trials.

The second annual Exploratory Clinical Development Congress addressed the critical issues in achieving seamless first in man studies and will also provide advice on how to conduct effective
studies that allow you to make the right decision early on in clinical development.

 

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APA Annual Meeting 2008

CDR attended the American Psychiatric Associations 161st Annual Meeting  on 3rd - 8th May, Washington, DC, USA. 


Washington, DC, was the site for the 2008 APA Annual Meeting. In addition to a wide variety of scientific offerings, the meeting provided a unique opportunity to meet with colleagues from around the world. The Scientific Program Committee had selected an outstanding group of cutting-edge scientific presentations from submissions that were of extremely high quality.
There was three presidential symposia presented on Monday, Tuesday, and Wednesday afternoons. There was numerous scientific presentations related to the theme and invited lecturers to
discuss various aspects of psychiatric practice, psychiatric education, and research. Special efforts were made to provide opportunities to learn more about and further discuss changes in the U.S. health care delivery system. An entire track of sessions, presented in collaboration with the National Institute on Mental Health, had been scheduled throughout the meeting.

 

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American Association for Technology in Psychiatry

CDR attended as delegates and Professor Keith Wesnes presented on "The Use of The CDR System, an Automated Test System for Assessing Cognitive Function in Drug Development" on 3rd May 2008, Washington, DC, USA.


The annual scientific meeting was held in conjunction with the American Psychiatric Association Annual Meeting. It included interesting presentations, electronic posters and an opportunity to learn, exchange ideas and collaborate with colleagues.

For more details Click Here.

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CBI's Drug Development for Neurodegenerative Conditions

CDR exhibited and Professor Keith Wesnes presented on "Leverage the Value Cognitive Testing Brings to Phase I and II" in Arlington, VA, USA April 30th - May 1st 2008.


The presentation from Professor Wesnes provided case examples of the value cognitive testing can bring to Phase I and Phase II trials to provide evidence of cognition enhancement which will help guide future drug development, help identify proof of concept and facilitate licensing deals in a variety of CNS indications.

For further details on the talk Click Here

 

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CDR PhD student success

We are delighted to announce that Crystal Haskell, one of Professor Keith Wesnes' PhD students, has recently been awarded her PhD from Northumbria University. Crystal was sponsored by CDR and used the CDR System to examine the biobehavioural effects of caffeine in isolation as well as in combination.

 

 

 


The findings of her thesis show that there are cognitive and mood benefits of caffeine which are not simply due to a reversal of withdrawal effects in regular caffeine users. Several studies also demonstrated psychostimulant properties of guaraná (an extract of a South American berry), but a comparison of this with caffeine suggested that these effects were not soley due to the caffeine content of guaraná. Modulation of the effects of caffeine was also observed in a study examining the effects of combining caffeine with L-theanine, an amino acid found in tea. The results showed that combining caffeine with L-theanine led to an enhancement of the effects of caffeine.

Crystal has to date published three papers employing the CDR System:

Haskell, C. F., D. O. Kennedy, et al. (2005). "Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine." Psychopharmacology 179(4): 813-25.

Haskell, C. F., D. O. Kennedy, et al. (2007). "A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guarana in humans." J Psychopharmacol 21(1): 65-70.

Haskell C.F., Kennedy DO, Milne AL, Wesnes KA, Scholey AB. “The effects of L-theanine, caffeine and their combination on cognition and mood.” Biological Psychology; 77 (2): 113-22

If you are considering The CDR System to further your career or for any sponsored or collaborative enquiries, please email enquiries@cognitivedrugresearch.com

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60th AAN Annual Meeting

CDR attended one of the world's largest gatherings of neurology professionals, which brought together more than 10,000 neurologists and neuroscientists to share groundbreaking research and participate in a comprehensive curriculum-based educational program: The 60th AAN Annual Meeting, April 12–19, 2008  Chicago, USA


The AAN Annual Meeting brought together more than 10,000 neuroscience professionals for one of the world's largest neurology gatherings. It has long been a leading showcase for the latest developments in scientific research, and the place to honor peers at the forefront of this work.
Opportunities in neuroscience include:


• Scientific Program Abstracts : Groundbreaking Scientific Program featuring over 1,600 abstracts on over 20 topics in clinical and basic science research.


• Plenary Sessions: Five premier Plenary Sessions feature lectures by esteemed investigators discussing critical advances in neuroscience.


• Scientific Topic Highlights: Highlights present the best research in select neurological topics from over 1,600 scientific poster and platform presentations.


• Late-Breaking Science: The most current research by neurologists, neuroscientists, and other eligible researchers whose work is of major scientific importance or interest and warrants expedited presentation and publication.


• Future of Neuroscience Conference: Neural Repair: A day-long scientific symposium that appeals to both clinical neurologists and neuroscientists. The program will feature invited speakers in the field as well as relevant abstracts.


• Integrated Neuroscience: An expansive look at Autism, Genetics of Epilepsy, Tropical Neurology, New Methods in Imaging, Stroke Imaging and Emerging Therapies, and Mitochondria in Diseases.


 

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BioTrinity 2008 Oxford

CDR attended the annual showcase event for the regional bioscience super-cluster, BioTrinity 2008 Oxford which brought together decision-makers from biotech and pharma together with expert professional advisers and VC finance representatives. April 15-16 2008, Oxford, UK.

Last year over 500 partnering meetings brought together more than 400 delegates from nearly 300 companies to discuss over 185 licensing opportunities. And this year the event was even bigger: for example, companies booked to present at BioTrinity 2008 Oxford had 33 compounds in pre-clinical development and 25 in clinical development, excluding big pharma participants. Add to that access to networking receptions, international panel discussions, company showcases and essential workshops all promised to make this the “must attend” event of the year.

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Neurocognitive effects of herbal medicines: Two decades of clinical trials

Prof Keith Wesnes presented at the 3rd International Congress on Complementary Medicine Research  ‘ICCMR 2008', Sydney, Australia, 29 to 31 March 2008.

The title of his talk “Neurocognitive effects of herbal medicines: Two decades of clinical trials”, was presented at the following symposium: “Herbal medicines for brain and behaviour: from bench to bedside”

 


Also speaking at the symposium were Professors Andrew Scholey and Con Stough, of the Brian Sciences Institute, Melbourne, where Professor Wesnes was appointed Adjunct Professor last November. During his stay, Keith worked with Con and Andrew on a number of national initiatives and research grants, and finalized the plans for the CDR laboratory in the custom built building the Institute will occupy later this year. The building will also house the Institute’s new fMRI scanner and Magneto EEG, and will become a leading centre for studying cognitive function in Australia.

For further information on ICCMR 2008 click here.

 

 

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ICR's Communication in Clinical Research - "Challenges in a Complex World"

CDR attended The Insititute of Clinical Research - 29th Annual Conference & Exhibition 2008 8th & 9th April at the ICC, Birmingham, UK.

 


The conference covered the following topics;

Discover the secrets behind media coverage of science

• Get updates on regulations from competent authorities

• Begin tackling the lifestyle diseases of tomorrow

• Discuss the impact of changes in the ethics environment

• Learn how to operate effectively in a global workplace

Meet your peers and make new contacts

Exhibition

The latest developments, meet your collaborators, and check out the competition at the biggest clinical research exhibition in Europe with over 140 stands.

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ASCPT 2008 Annual Meeting

CDR exhibited at booth number 110 and Steve Satek presented on "The Use of Cognitive Function Testing To Identify Potential Cognition Enhancers In Phase I: Case Histories of Translational Medicine" on April 02-05 2008, Orlando, Florida USA.

 


Over 1,200 professionals in the field of clinical pharmacology attend the ASCPT Annual Meeting, which features comprehensive state-of-the-art lectures, first-class scientific symposia and workshops. In addition, over 325 poster presentations highlight the most recent advances in pharmacology and therapeutics.

Click Here to view Steve Satek's presentation on "The Use of Cognitive Function Testing To Identify Potential Cognition Enhancers In Phase I: Case Histories of Translational Medicine"

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CNS Drug Development Summit

Brian Saxby, Head of Science at CDR, presented at The CNS Drug Development Summit on 2-3 April 2008, City Conference Centre, London, UK. 

The title of his talk was "Computerised cognitive testing in clinical trials of dementia prevention and cognitive decline: hypertension and stroke"


His talk covered the following areas:

  • EMEA draft guidelines for treatment of AD and other dementias: cognitive outcomes
  • The Cognitive Drug Research computerised assessment battery
  • Primary prevention strategies
  • Hypertension: results from the SCOPE cognitive substudy
  • Stroke: the ongoing PRoFESS-COG study

For further details or to contact Brian Saxby Click Here

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DIA's 20th Annual EuroMeeting 2008

CDR exhibited at DIA's 20th Annual EuroMeeting held in Barcelona Spain, 3rd - 5th March 2008


DIA's 20th Annual EuroMeeting was global in scope, attracting more than 3,000 industry professionals from over 50 countries. Europe's annual flagship event offered timely and relevant session topics, continuing education, networking opportunities, and access to the bigger than ever exhibit hall.

This one-of-a-kind meeting brought together professionals from the biopharmaceutical industry, contract service organizations, academic research centers, and regulatory agencies. This convergence affords attendees the opportunity to network with professional colleagues from around the world. With more than 100 sessions and 10 themes, the annual event covered a variety of cross-disciplinary topics—from regulatory to health economics.

Industry professionals can become a DIA member and attend the future DIA events at a reduced price. 

To register now Click Here

 

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Hong Kong/Springfield Pan-Asian Symposium on Advances in Alzheimer Therapy - Feb 28th - 1st March 2008

Brian Saxby, Head of Science, presented a poster at the Hong Kong/Springfield Pan-Asian Symposium on Advances in Alzheimer Therapy.  

His poster number 24956 entitled "Measurement of Episodic Memory Using Word Tasks in Character-Based Languages: Validation From A Multicentre Clinical Trial.


The Hong Kong/Springfield Pan-Asian Symposium on Advances in Alzheimer Therapy was held at the Kowloon Shangri-La Hotel, Hong Kong on 28th February - 1st March 2008

To view the poster click here

 

 

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December 2007: SURVEY FINDS INDUSTRY PROFESSIONALS PREFER CDR

 

Scientific knowledge, quality of test battery and breadth of experience cited as key reasons. 

A survey by a prominent U.S. marketing firm confirms that industry professionals prefer Cognitive Drug Research (CDR) for cognitive assessment studies.


A survey by a prominent U.S. marketing firm confirms that industry professionals prefer Cognitive Drug Research (CDR) for cognitive assessment studies.

            The overwhelming majority had used CDR for past studies and had chosen them based on:

  • Scientific knowledge and expertise
  • Quality of the test battery for the specific disease being tested
  • Past experience with the specific disease state being tested

            When asked who they viewed as the market leader in cognitive assessment, a similarly large percentage named CDR.

            Why do professionals prefer CDR? Here are some of their specific comments:

“CDR has a long history in cognitive assessment as well as an impressive portfolio of studies, past clients and databases. In addition to that, we use CDR because of their reliability and the ease of flow of their system.”

n      International CRO

 

“CDR is very efficient. That, combined with their reputation and experience, is why we selected them for our last cognitive study.”

n      Major pharmaceutical manufacturer

 

“CDR is definitely an industry leader in Phase I and nicotinic studies as evidenced by the significant amount of published data CDR has available in these areas.”

n      Major pharmaceutical manufacturer

 

“We use CDR because they are the best.”

n      Major pharmaceutical manufacturer

 

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International Clinical Trials publishes article on cognition testing and translational medicine written by CDR's scientific team

International Clinical Trials publishes an article written by CDR's scientific team on translational medicine and the utility of cognitive testing in routine phase 1 safety and tolerability trials in its autumn issue.


The article describes the advantages of using automated cognitive assessments over traditional pencil and paper tasks and illustrates how cognitive assessments have been used successfully as a translational tool to support compound development decisions.

To view the article, please click here

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CDR short-listed for best CRO at the 2007 SCRIP Awards!

CDR were extremely proud to be selected alongside full service CROs in recognition of the services they provide in addition to cognitive testing - from protocol development, site training, 24h service, statistics and reporting to presentation of findings. These service assets set CDR apart from other test providers.

 


The annual awards competition, organised by Scrip World Pharmaceutical News, a leading provider of news and analysis for the global biopharmaceutical industry, is designed to recognise new standards of excellence and celebrate achievements that reflect cutting-edge science and the intellectually exciting and socially rewarding nature of the industry.

CDR rewarded it's staff for their hard work by randomly selecting a number of personnel to join the CDR Board in their celebrations. Well Done CDR!

 

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Amarin Corporation Plc (AMRN) announces Phase II trial using The CDR System in Age Associated Memory Impairment

Amarin Corporation Plc have announced the commencement of a Phase IIa trial in Age Associated Memory Impairment (AAMI) with AMR101 (ultra-pure ethyl-EPA).

The trial will be a randomised, double-blind, placebo-controlled study. The trial will enroll 96 patients with AAMI who will be randomised to receive 1, 2 or 4 grams of AMR101 or placebo twice daily over a six-week period.

A press release on 10th January 2008 highlighted that: 'Efficacy will be assessed by a computerised battery of cognition tests designed by Cognitive Drug Research (CDR) Ltd, a world leader in the provision of innovative cognitive function assessment technology'.


The study is being conducted in the U.K. and patient recruitment is expected to commence shortly, with initial results expected in the second half of 2008.

For more information about this exciting new trial please visit Biospace news.

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The British Psychological Society Psychobiology Section Annual Conference

Brian Saxby, Scientific Development Manager, spoke at the conference in the Lake District (3rd-5th September) about the relationship between blood biomarkers and cognitive recovery after cardiac surgery, assessed using the CDR System.


In addition, Brian presented two posters: the scopolamine model of dementia, validated against clinical rating scales using an effect size methodology; and a responder analysis of epoetin alfa treatment in chemotherapy for the EPOLYM Investigators.

Please click here to view Brian's oral presentation.

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Alzheimer's Drug Development Summit

Professor Keith Wesnes presented at the Alzheimer's Drug Development Summit in the USA, November 29 - 30 2007, Arlington, VA.

Professor Wesnes spoke during the Day 2 section on early warning systems and novel cognitive assessment for Alzheimer's Disease, read on to find out more........


Time to move forward: Computerised cognitive assessments come of age in dementia research. The International Working Group on Dementia Drug Guidelines (Ferris et al, 1997) concluded that computerised cognitive testing may supersede the ADAS if advantages were established. The CDR Computersied Assessment System has been in use in worldwide dementia drug trials for over 20 years and has a number of advantages over the ADAS including the ability to assess attention and information processing. Its utility, reliability, validity, sensitivity, clinical and everyday relevance will be described. The CDR System has shown high sensitivity to cognitive benefits in Alzheimer's, Parkinson's and Lewy Body Dementia and is currently being used as the primary outcome variable in several early trials of nicotinic agonists in Alzheimer's disease.

  • Appreciate the added value of fully establishing the cognitive benefit profile of an antidementia drug
  • Learn how sensitive procedures can aid dose selection and proof of concept in Phase II
  • The degree of return to cognitive normality: an ultimate measure of clinical relevance in dementia
  • Avoid the risk of trial failure now the ADAS cannot be relied upon to detect progressive decline in placebo treated patients

This timely inaugural summit examined the latest disease modifying therapies and pre-symptomatic approaches for Alzheimer's. Topics included: Key market barriers of Alzheimer's drug development, the importance of translational medicine in AD drug development, the public and private partnership role in the NIH ADNI project and much more!

 

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LEXICON initiates trial of drug candidate for cognitive disorders using CDR Battery

Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX) has announced that dosing has commenced in a Phase 2a clinical trial with LX6171, an oral drug candidate for the treatment of cognitive impairment associated with disorders such as Alzheimer's disease, schizophrenia, and vascular dementia.


The initial stage of the trial will assess the bioavailability of a new oral-suspension formulation in healthy elderly subjects with a second stage evaluating safety, tolerability and cognitive effects in elderly subjects with age-associated memory impairment (AAMI).

 

"AAMI is an emerging area of clinical research and offers an expedient population for obtaining proof-of-concept with a drug candidate, like LX6171, that has a broad range of potential applications in the area of cognitive disorders," said Philip M. Brown, M.D., J.D., vice president of clinical development at Lexicon. "Following the strength of the Phase 1 data indicating LX6171 is generally well tolerated, we have adopted a two-stage strategy for Phase 2a in order to transition to our new oral suspension formulation and to assess for improvements in a variety of cognitive dimensions as we enter the elderly population."

Phase 2 Study Design

The initial stage of the trial will assess the bioavailability of a single-dose oral suspension in 16 healthy elderly subjects. The second stage will be a randomized, double-blind, placebo-controlled evaluation of safety, tolerability, and cognitive effects in approximately 120 subjects over four weeks. This stage is anticipated to include three groups of 40 subjects each, exploring two dose levels with a placebo control. Exact dose levels for the second stage will be set based on evaluation from the first stage pharmacokinetic study using the new formulation. The second stage will evaluate the safety and tolerability of LX6171 oral suspension in subjects exhibiting AAMI and will measure the cognitive effects of LX6171 in these subjects using the Cognitive Drug Research battery, along with other psychometric instruments. The study is being conducted in Europe, with initial results expected by the end of 2008.

About LX6171

LX6171 is an orally-bioavailable small molecule developed by Lexicon scientists to inhibit a membrane protein expressed exclusively in the central nervous system and found at synaptic vesicles and presynaptic membranes of glutamatergic neurons. The protein targeted by LX6171 was identified through Lexicon's large-scale gene knockout program, the Genome5000T. Knockout mice lacking this protein showed improved learning and memory compared with controls. In preclinical studies, administration of LX6171 resulted in improved performance in tests of learning and memory in mice. In Phase 1 clinical trials, LX6171 was generally well tolerated at all dose levels and showed good systemic exposure.

About Lexicon

Lexicon is a biopharmaceutical company focused on the discovery and development of breakthrough treatments for human disease. Lexicon currently has clinical programs underway for such areas of major unmet medical need as irritable bowel syndrome, cognitive disorders, and rheumatoid arthritis. The company has used its proprietary gene knockout technology to discover more than 100 promising drug targets and create an extensive pipeline of clinical and preclinical programs in the therapeutic areas of diabetes and obesity, cardiovascular disease, psychiatric and neurological disorders, cancer, immune system disorders and ophthalmic disease. To advance the development and commercialization of its programs, Lexicon is working both independently and through collaborators including Bristol-Myers Squibb Company, Genentech, Inc. and N.V. Organon. For additional information about Lexicon and its programs, please visit the company's web site www.lexpharma.com

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Clinical Trials in CNS

Professor Keith Wesnes chaired Day 1 and spoke at SMi's Clinical Trials in CNS Conference in London on 26th & 27th November 2007.

The title of his talk was "Cognitive testing in drug development: latest developments and hot topics"


The talk covered the following areas:

Automated equivalents to the MATRICS Consensus Cognitive Battery

  • Selective nicotinic agonists for cognition enhancement
  • ‘Wakefulness’: a new therapeutic target
  • Is there a viable automated alternative to the ADAS?
  • Cognitive testing in translational medicine comes of age

Professor Wesnes was joined at this event by our Vice President of Business Development (US & Canada) Steve Satek and our Head of Business Development (Europe & Asia) Mark Cusack.

To hear more about Keith's presentation please do contact Mark or Steve.

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Great CDR test results on two prominent Alzheimer's Disease trials

CDR is delighted to announce that a paper based on data from the CDR System in two Alzheimer’s trials, one run in the UK and then other in the USA, has just been accepted for publication in the journal, Alzheimer’s Disease and Related Disorders.


The paper is entitled "Effects of Galantamine on Measures of Attention: Results from two Clinical Trials in Alzheimer’s Disease Patients with Comparisons to Donepezil". The authors are: James Galvin, Barbara Cornblatt, Paul Newhouse, Sonia Ancoli-Israel, Keith Wesnes, David Williamson, Young Zhu, Karin Sorra and Joan Amatniek.
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American Association of Pharmaceutical Scientists (AAPS)

 

CDR exhibited at the American Association of Pharmaceutical Sc